INY-03-041

• Target:

  Akt|||PROTACs

• Related Pathways:

  PROTAC|||PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling

• Bioactivity:

  INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. This compound consists of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide.

• Smiles:

  O=C (C (N (CC1=C2C=CC=C1CCCCCCCCCCNC[C@H] (C3=CC=C (Cl) C=C3) C (N4CCN (C5=C ([C@H] (C) C[C@H]6O) C6=NC=N5) CC4) =O) C2=O) CC7) NC7=O

• Molecular Formula:

  C44H56ClN7O5

• Molecular Weight:

  798.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C