INY-03-041

• Target :

  Akt|||PROTACs

• Related Pathways :

  PROTAC|||PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling

• Bioactivity :

  INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. This compound consists of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide.

• Smiles :

  O=C(C(N(CC1=C2C=CC=C1CCCCCCCCCCNC[C@H](C3=CC=C(Cl)C=C3)C(N4CCN(C5=C([C@H](C)C[C@H]6O)C6=NC=N5)CC4)=O)C2=O)CC7)NC7=O

• Molecular Formula :

  C44H56ClN7O5

• Molecular Weight :

  798.41

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C