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Z-3578

CAT: 0931-T206382-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T206382-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
473687-20-6
Target
MRGPR|||TNF
Related Pathways
GPCR/G Protein|||Apoptosis
Bioactivity
Z-3578 is a small molecule antagonist targeting the MrgX2 (Mas-related G protein-coupled receptor X2) with notable anti-pseudoallergic properties, exhibiting a KD value of 729 nM. It effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, with IC50 values of 4.90 µM and 6.18 µM, respectively, suppresses the release of ?-hexosaminidase, and significantly reduces the release of histamine and TNF-?, as well as intracellular calcium flux. Additionally, in a mouse pseudoallergy model, Z-3578 significantly alleviates foot swelling, dye leakage, and reduces serum histamine levels, indicating a strong in vivo anti-allergic effect. Z-3578 presents as a promising lead compound in the field of anti-allergic treatments, particularly for pseudoallergic reactions.
Smiles
O=C(NC1=CC=C(Cl)C=C1Cl)CSC=2N=NC(C3=CC=CC=C3)=C(N2)C=4C=CC=CC4
Molecular Formula
C23H16Cl2N4OS
Molecular Weight
467.37
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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