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DC4SMe

CAT: 0931-T10976-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T10976-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
615538-47-1
Target
ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
The IC50s of DC4SMe on Ramos, Namalwa and HL60 / s cancer cells were 1.9 nM, 2.9 nM and 1.8 nM, respectively. DC4SMe can be used for targeted therapy of tumors. DC4SMe is a phosphate prodrug of the cytotoxic DNA alkylating agent DC4 and can be used in the synthesis of antibody-drug conjugates (ADC) .
Smiles
C(Cl)[C@H]1C2=C(N(C(=O)C3=CC=4C(N3)=CC=C(NC(=O)C5=CC=6C(N5)=CC=C(NC(CCSSC)=O)C6)C4)C1)C=C(OP(=O)(O)O)C=7C2=CC=CC7
Molecular Formula
C35H31ClN5O7PS2
Molecular Weight
764.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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