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CSN5i-3

CAT: 0931-T10895-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T10895-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2375740-98-8
Target
Apoptosis, Others
Related Pathways
Others, Apoptosis
Purity
>99.99%
Bioactivity
CSN5i-3 is a potent, selective, and orally available inhibitor of the proteolytic subunit of the CSN complex, CSN5. It inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM. CSN5i-3 has a killing effect on a variety of cancer cells and can be used as an anticancer drug. [2]
Smiles
CC(C)n1nc(cc1C(=O)Nc1ccc([C@H]2[C@@H](O)CCCc3cncn23)c(c1)-c1ccccc1)C(F)F
Molecular Formula
C28H29F2N5O2
Molecular Weight
505.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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