CHMFL-ABL/KIT-155

• Target:

  Bcr-Abl|||c-Kit|||PDGFR|||Discoidin Domain Receptor (DDR) |||Apoptosis

• Related Pathways:

  Apoptosis|||Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

• Bioactivity:

  CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM) . It arrests cell cycle progression and induces apoptosis.

• Smiles:

  C (C1=C (C (F) (F) F) C=C (C (NC2=CC (OC3CCN (C (=O) C=4C=CC (C) =NC4) CC3) =C (C) C=C2) =O) C=C1) N5CCN (C) CC5

• Molecular Formula:

  C33H38F3N5O3

• Molecular Weight:

  609.68

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2081093-21-0