CHMFL-ABL/KIT-155

• Target :

  Bcr-Abl|||c-Kit|||PDGFR|||Discoidin Domain Receptor (DDR) |||Apoptosis

• Related Pathways :

  Apoptosis|||Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

• Bioactivity :

  CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM) . It arrests cell cycle progression and induces apoptosis.

• Smiles :

  C(C1=C(C(F)(F)F)C=C(C(NC2=CC(OC3CCN(C(=O)C=4C=CC(C)=NC4)CC3)=C(C)C=C2)=O)C=C1)N5CCN(C)CC5

• Molecular Formula :

  C33H38F3N5O3

• Molecular Weight :

  609.68

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2081093-21-0