CHMFL-ABL-053

• Target:

  Others|||p38 MAPK|||Bcr-Abl|||Src

• Related Pathways:

  Cytoskeletal Signaling|||Others|||Angiogenesis|||Tyrosine Kinase/Adaptors|||MAPK

• Bioactivity:

  CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available inhibitor of BCR-ABL, SRC, and p38 kinases, with IC50 values of 70, 90, and 62 nM against ABL1, SRC, and p38, respectively. CHMFL-ABL-053 is a potentially useful drug candidate for Chronic Myeloid Leukemia (CML) [1].

• Smiles:

  N(C=1N=C(NC)C(C(NC2=CC(NC(=O)C3=CC(C(F)(F)F)=CC=C3)=CC=C2C)=O)=CN1)C4=CC(N)=C(C)C=C4

• Molecular Formula:

  C28H26F3N7O2

• Molecular Weight:

  549.55

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1808287-83-3