CHMFL-ABL-053

CAT: 0931-MF-0051246-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0051246-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1808287-83-3
Target
Others|||p38 MAPK|||Bcr-Abl|||Src
Related Pathways
Cytoskeletal Signaling|||Others|||Angiogenesis|||Tyrosine Kinase/Adaptors|||MAPK
Bioactivity
CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available inhibitor of BCR-ABL, SRC, and p38 kinases, with IC50 values of 70, 90, and 62 nM against ABL1, SRC, and p38, respectively. CHMFL-ABL-053 is a potentially useful drug candidate for Chronic Myeloid Leukemia (CML) [1].
Smiles
N(C=1N=C(NC)C(C(NC2=CC(NC(=O)C3=CC(C(F)(F)F)=CC=C3)=CC=C2C)=O)=CN1)C4=CC(N)=C(C)C=C4
Molecular Formula
C28H26F3N7O2
Molecular Weight
549.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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