2',3'-cGAMP

• Target:

  Immunology/Inflammation related|||COX|||cGAS|||STING|||Endogenous Metabolite|||IFNAR

• Related Pathways:

  Metabolism|||Neuroscience|||Immunology/Inflammation

• Purity:

  0.9865

• Bioactivity:

  2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-?B pathway.

• Smiles:

  O[C@H]1[C@@]2 ([C@@H] (O[C@]1 (COP (=O) (O) O[C@@]3 ([C@@] (COP (=O) (O) O2) (O[C@H] ([C@@H]3O) N4C=5C (N=C4) =C (N) N=CN5) [H]) [H]) [H]) N6C7=C (N=C6) C (=O) N=C (N) N7) [H]

• Molecular Formula:

  C20H24N10O13P2

• Molecular Weight:

  674.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1441190-66-4