2',3'-cGAMP

• Target :

  Immunology/Inflammation related|||COX|||cGAS|||STING|||Endogenous Metabolite|||IFNAR

• Related Pathways :

  Metabolism|||Neuroscience|||Immunology/Inflammation

• Purity :

  0.9865

• Bioactivity :

  2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-?B pathway.

• Smiles :

  O[C@H]1[C@@]2([C@@H](O[C@]1(COP(=O)(O)O[C@@]3([C@@](COP(=O)(O)O2)(O[C@H]([C@@H]3O)N4C=5C(N=C4)=C(N)N=CN5)[H])[H])[H])N6C7=C(N=C6)C(=O)N=C(N)N7)[H]

• Molecular Formula :

  C20H24N10O13P2

• Molecular Weight :

  674.41

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1441190-66-4