Coumalic acid

• Description:

  Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (KI = 0.073 μM for hCA IX; KI = 0.083 μM for hCA XII) . Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR) ; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/coumalic-acid.html

• Purity:

  97.65

• Solubility:

  DMSO : 250 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(O)C(C=C1)=COC1=O

• Molecular Formula:

  C6H4O4

• Molecular Weight:

  140.09

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Smith LK, et, al. Flow synthesis of coumalic acid and its derivatization. Department of Chemistry. 2018, 3: 722-732.|[2]Pontecorvi, V., et al., (2022) . Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies. International journal of molecular sciences, 23 (14), 7950.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  500-05-0