Coumalic acid

CAT: 0804-HY-32004-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-32004-01Size:500 mg
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Description
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (KI = 0.073 μM for hCA IX; KI = 0.083 μM for hCA XII) . Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity[1][2].
CAS Number
[500-05-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR) ; Parasite
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/coumalic-acid.html
Purity
97.65
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C(C=C1)=COC1=O
Molecular Formula
C6H4O4
Molecular Weight
140.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Smith LK, et, al. Flow synthesis of coumalic acid and its derivatization. Department of Chemistry. 2018, 3: 722-732.|[2]Pontecorvi, V., et al., (2022) . Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies. International journal of molecular sciences, 23 (14), 7950.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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