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TIM3 Antibody / HAVCR2

CAT: 0013-GTR18575340Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18575340Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cel tonsil, lymph node or spleen. ls (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2) . In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
UniProt
Q8TDQ0
Reactivity
Human
Immunogen
A portion of amino acids 22-202 from the human protein was used as the immunogen for the TIM3 antibody.
Clonality
Monoclonal
Clone
TIM3/4031
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
Western blot: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the TIM3 antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · Q8TDQ0

Hepatitis A virus cellular receptor 2

HAVR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TDQ0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HAVCR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HAVcr-2
EC number
—
Processing
Precursor
Secondary accessions
B2RAY2, Q8WW60, Q96K94
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInflammatory responseInnate immunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Ligand

Metal-binding

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