Active Cathepsin D, Human Recombinant

CAT: 0026-9229-50Size: 50 µgDry Ice: NoHazardous: No
CAT#:0026-9229-50Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D. BioVision’s Active Human Cathepsin D is a proteolytically active, non-glycosylated enzyme expressed, purified and activated by proprietary methods.
CAS Number
9000-83-3
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
6 months

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