KW-2449 hydrochloride

CAT: 0026-B1208-25Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0026-B1208-25Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. It displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase. This leads in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis. KW 2449 induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis in FLT3 wild-type human leukemia.

Shipping Conditions

gel pack

Storage Conditions

-20°C

Shelf Life

36 months

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RIB25917-01	KW-2449 hydrochloride
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KW-2449 hydrochloride

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