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MPEP hydrochloride

CAT: 0026-B1151-10Size: 10 mgDry Ice: NoHazardous: No
CAT#:0026-B1151-10Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MPEP hydrochloride is a highly selective and potent non-competitive antagonist at the mGlu5 (metabotropic glutamate receptor subtype 5) receptor subtype (IC₅₀ = 36 nM). It is a positive allosteric modulator at mGlu4. MPEP hydrochloride reduces DHPG (S-3, 5-dihydroxyphenylglycine)-induced excitations but not the excitations induced by AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). In vivo studies show it reverses mechanical hyperalgesia in the inflamed rat hind paw.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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