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Skepinone-L

CAT: 0026-B1110-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B1110-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Skepinone-L is a potent, ATP-competitive inhibitor of p38 MAPK isoform p38α (IC₅₀ = 5 nM) and p38β (97% inhibition at 1 µM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin (Cat. No. 1549) in HeLa cells (IC₅₀ = 25 nM) or TNF-α in THP-1 cells.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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