ACY-1215

CAT: 0026-2629-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-2629-25Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACY-1215 is a potent, cell-permeable and selective inhibitor of histone deacetylase 6 (HDAC6) (IC₅₀ = 5 nM). ACY-1215 is 12-, 10-, 11 and 21-fold less active against HDAC1, HDAC2, HDAC3 and HDAC8, respectively. It displays minimal activities (IC₅₀ > 1 µM) against HDAC4, HDAC5, HDAC7, HDAC9, HDAC11, Sirtuin1, and Sirtuin2. In combination with Tubastatin (Cat. No. 1724), it improves cognition in Alzheimer’s Disease (AD) transgenic mice.
Shipping Conditions
Gel pack
Storage Conditions
-20 ̊C
Shelf Life
36 months

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