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ONX-0914

CAT: 0026-2555-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-2555-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. It selectively inhibits low–molecular mass polypeptide-7 (LMP7, encoded by Psmb8), the chymotrypsin-like subunit of the immunoproteasome (IC₅₀ < 100 nM). ONX-0914 blocks presentation of LMP7-specific, MHC-I–restricted antigens in vitro and in vivo. Selective inhibition of LMP7 by ONX-0914 blocks production of interleukin-23 (IL-23) by activated monocytes and interferon-g and IL-2 by T cells.
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
24 months

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Alternative Products

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HY-13207-01ONX-0914
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A12653-50ONX-0914 50mg
A12653-5ONX-0914 5mg
T73986-01ONX-0914 TFA
A12653-25ONX-0914 25mg
HY-13207A-01ONX-0914 (TFA)
A12653-100ONX-0914 100mg
A12653-10ONX-0914 10mg
A12653-1ONX-0914 1mg

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