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CRT Inhibitor, iCRT5

CAT: 0026-1896-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-1896-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cell-permeable. A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC₅₀ of 18 nM. It acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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