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ICRT5

CAT: 0013-GTR19197499-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19197499-01Size:5 mg
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Description
ICRT-5 is a potent small molecule Wnt/β-catenin pathway inhibitor with demonstrated antiproliferative and pro-apoptotic activity. It is a valuable research tool for studying Wnt-driven pathologies, including multiple myeloma, in both in vitro and in vivo experimental models.
CAS Number
18623-44-4
Product Name Alternative
ICRT 5, iCRT5, iCRT-5, betacatenin, beta-catenin, Apoptosis, bcatenin, Wnt/β-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin, βcatenin
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
B-catenin inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml)
Smiles
COc1ccc (\C=C2/SC (=S) N (CCCC (O) =O) C2=O) cc1OC
Molecular Formula
C16H17NO5S2
Molecular Weight
367.44
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[5- (3,4-Dimethoxy-benzylidene) -4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid

Chemical Information

4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid

ICRT5 is an organic molecular entity. It has a role as a Wnt signalling inhibitor.

CAS Number18623-44-4
PubChem CID1416325
IUPAC Name4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid
Molecular FormulaC16H17NO5S2
Molecular Weight367.4
XLogP2.8
Topological Polar Surface Area133
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count24
Formal Charge0
Complexity537
SMILES
COC1=C(C=C(C=C1)/C=C\2/C(=O)N(C(=S)S2)CCCC(=O)O)OC
InChI
InChI=1S/C16H17NO5S2/c1-21-11-6-5-10(8-12(11)22-2)9-13-15(20)17(16(23)24-13)7-3-4-14(18)19/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,19)/b13-9-
InChIKey
IJWKSBPTJQMUHJ-LCYFTJDESA-N
Chemical Structure
2D Structure
2D structure of 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid
CAS: 18623-44-4
CID: 1416325
Formula: C16H17NO5S2
MW: 367.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight367.4
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass367.05481499
Monoisotopic Mass367.05481499
Topological Polar Surface Area133 Ų
Heavy Atom Count24
Formal Charge0
Complexity537
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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