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COX-2 Inhibitor Screening Kit (Fluorometric)

CAT: 0026-K547-100Size: 100 AssaysDry Ice: NoHazardous: No
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CAT#:0026-K547-100Size:100 Assays
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 1.14.99.1), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. There are two known isoenzymes: COX-1 and COX-2. COX-1 is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in kidney. COX-2 is not expressed under normal conditions in most cells, but elevated levels are found during inflammation. Pharmacological inhibition of COX by non-steroidal anti-inflammatory drugs (NSAID) can provide relief from the symptoms of inflammation and pain. BioVision’s COX-2 Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of COX-2 inhibitors. The assay is based on the fluorometric detection of Prostaglandin G2, the intermediate product generated by the COX enzyme.
Applications
Screening/studying/characterizing COX-2 inhibitors.
Detection Method
Fluorescence (Ex/Em = 535/587 nm)
Features & Benefits
• Simple method to screen COX-2 inhibitors • High-throughput • Includes Inhibitor Control, Celecoxib
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
12 months

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