Roxatidine

• Description:

  Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Caspase; Histamine Receptor; NF-κB; p38 MAPK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/roxatidine.html

• Purity:

  98.25

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCCOC1=CC=CC(CN2CCCCC2)=C1)CO

• Molecular Formula:

  C17H26N2O3

• Molecular Weight:

  306.41

• Precautions:

  H302

• References & Citations:

  [1]Lee M, et al. Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation. Sci Rep. 2017;7:41721. Published 2017 Jan 31. |[2]Collins JD, et al. Pharmacokinetics of roxatidine in healthy volunteers. Drugs. 1988;35 Suppl 3:41-7. |[3]Cho EJ, et al. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. J Cell Biochem. 2011 Dec;112 (12) :3648-59.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  H2 Receptor

• CAS Number:

  [78273-80-0]