Chlorhexidine (digluconate)

Chlorhexidine (digluconate)

• CAS Number: 18472-51-0
• UNSPSC Description: Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis[1][2][3].
• Target Antigen: Antibiotic; Apoptosis; Bacterial; Necroptosis
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis
• Applications: COVID-19-anti-virus
• Field of Research: Infection; Cancer
• Assay Protocol: https://www.medchemexpress.com/chlorhexidine-digluconate.html
• Purity: 99.45
• Solubility: DMSO : ≥ 38 mg/mL|H2O : 100 mg/mL (ultrasonic)
• Smiles: N=C(NC(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)=N)NC2=CC=C(Cl)C=C2.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO
• Molecular Weight: 897.76
• References & Citations: [1]Wael E Shams, et al. Peritoneal Lavage Using Chlorhexidine Gluconate at the End of Colon Surgery Reduces Postoperative Intra-Abdominal Infection in Mice. J Surg Res. 2015 May 1;195(1):121-7.|[2]Yi-Ching Li, et al. Assessment of the cytotoxicity of chlorhexidine by employing an in vitro mammalian test system. Journal of Dental Sciences. Volume 9, Issue 2, June 2014, Pages 130-135.|[3]Hon-Yeung Cheung, et al. Differential actions of chlorhexidine on the cell wall of Bacillus subtilis and Escherichia coli. PLoS One. 2012;7(5):e36659.Antioxidants (Basel). 2024 May 29;13(6):667.|bioRxiv. 2024 Nov 06.|Cell Death Dis. 2022 Apr 22;13(4):396.|Cell Signal. 2021 Apr 3;110002.|Front Cell Dev Biol. 30 March 2021.|Genes (Basel). 2021, 12(4), 537.|J Funct Foods. 2024 Jun.|Mol Oncol. 2020 Feb;14(2):373-386. |Nat Commun. 2021 Mar 29;12(1):1940.|Transl Oncol. 2024 Apr 24:45:101958.
• Shipping Conditions: Blue Ice
• Storage Conditions: Solution, -20°C, 2 years
• Clinical Information: Launched