Products for Research Use Only
RegisterLogin

3-TYP

CAT: 0804-HY-108331-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-108331-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO) . There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases[1][2][3].
CAS Number
120241-79-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Indoleamine 2,3-Dioxygenase (IDO) ; Methionine Adenosyltransferase (MAT) ; Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-TYP.html
Purity
99.96
Solubility
DMSO : 125 mg/mL (ultrasonic) |Ethanol : 16.67 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(C2=CN=NN2)=CC=CN=C1
Molecular Formula
C7H6N4
Molecular Weight
146.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11 (7) :1037-51.|[2]Zhai M, et al. Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 2017 Sep;63 (2) .|[3]Galli U, et al. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem. 2012 Sep;55:58-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT3

Related Products

CatalogName
HY-W081226-013,3,3-Trifluoropropionyl chloride
HY-W127810-013,3',3''-Nitrilotripropionic Acid
HY-174161Type II TRK inhibitor 3
HY-W1146693- (3- (3-Ethoxy-3-oxopropoxy) propoxy) propanoicacid
HY-D1075-011,1',3,3,3',3'-Hexamethylindodicarbocyanine (iodide)
HY-W4403031,1',3,3,3',3'-Hexamethylindotricarbocyanine (perchlorate)
HY-14611-013,3'-Difluorobenzaldazine
HY-15758-013,3'-Diindolylmethane
HY-79034-013,3-Dimethylcyclohexanone
HY-131942SFTX-3.3

Alternative Products

CatalogName
BA4504-1003-TYP

Popular Products