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αC-Conotoxin PrXA

CAT: 0804-HY-P5149-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P5149-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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UNSPSC Description
αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA competes with α-bungarotoxin at the α/δ and α/γ subunit interfaces of the nAChR, shows high specificity against neuromuscular nAChR[1].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
98.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(CCC1)C([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H]([C@@H](C)CC)NC(CNC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)N4[C@@H](C[C@H](C4)O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H]5C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H](CSSC5)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N6[C@@H](CCC6)C(N7[C@@H](C[C@H](C7)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N8[C@@H](C[C@H](C8)O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CCC(O)=O)=O)=O)CC9=CC=CC=C9)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC%10=CC=CC=C%10)=O
Molecular Weight
3541.06
References & Citations
[1]Jimenez EC, et al. AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry. 2007 Jul 31;46(30):8717-24.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Clinical Information
No Development Reported

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