D-Mannitol

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7]. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed[8].

69-65-8

Mannitol; Mannite

12352211

H302

Adrenergic Receptor; Apoptosis; Endogenous Metabolite; PGC-1α; PKA

Natural Products

Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad

Metabolism-protein/nucleotide metabolism

Metabolic Disease; Cancer; Cardiovascular Disease

https://www.medchemexpress.com/D-Mannitol.html

10mM

99.93

H2O : ≥ 36 mg/mL

OC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

C6H14O6

182.17

H302

[1]Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284 (52) : p. 36670-9.|[2]Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55 (3) : p. 242-51.|[3]Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80 (2) : p. 157-62.|[4] Xiao J, et al. Sakaguchi E. Mannitol improves absorption and retention of calcium and magnesium in growing rats. Nutrition. 2013;29 (1) :325-331.|[5]Kaufmann AM, et al. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg. 1992;77 (4) :584-589.|[6]Paczynski RP, et al. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke. 1997;28 (7) :1437-1444.|[7]Jeon HJ, et al. D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism. Cells. 2021;10 (4) :768. Published 2021 Mar 31. |[8]Zhou, Y., et al. Pathogenesis-related proteins induced by agroinoculation-associated cell wall weakening can be obviated by spray-on inoculation or mannitol ex vivo culture. Plant Biotechnol Rep 11, 161-169 (2017) .

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

Natural Products

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