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Lintuzumab

CAT: 0804-HY-P9983-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P9983-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice[1].
CAS Number
166089-32-3
Product Name Alternative
SGN-33; HuM-195
UNSPSC
12352203
Target
Radionuclide-Drug Conjugates (RDCs) ; Transmembrane Glycoprotein
Type
Inhibitory Antibodies
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lintuzumab.html
Purity
98.09
Solubility
H2O
Smiles
[Lintuzumab]
Molecular Weight
(145.24 kDa)
References & Citations
[1]Lintuzumab|[2]Sutherland, M. K., et al., (2009) . Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia. mAbs, 1 (5), 481–490.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3
Isoform
RDC Antibody

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