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5-Methyl-7-methoxyisoflavone

CAT: 0804-HY-N1993-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1993-01Size:10 mg
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Description
5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone. 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB[1][2][3][4].
CAS Number
82517-12-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450; NF-κB
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5-methyl-7-methoxyisoflavone.html
Purity
99.13
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=CC=C2)=COC3=CC(OC)=CC(C)=C13
Molecular Formula
C17H14O3
Molecular Weight
266.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Ningbo Gong, et al. Concomitant polymorphs of methoxyflavone (5-methyl-7-methoxyflavone) . RSC Adv., 2016, 6, 38709-38715.|[2]Agresti C, et al. Oxidative status in multiple sclerosis and off-targets of antioxidants: the case of edaravone[J]. Current Medicinal Chemistry, 2020, 27 (13) : 2095-2105.|[3]Iannone M, et al. An investigation on the metabolic pathways of synthetic isoflavones by gas chromatography coupled to high accuracy mass spectrometry. Rapid Commun Mass Spectrom. 2019 Oct 15;33 (19) :1485-1493. |[4]Lecompte Y, et al. UPLC-ESI-Q-TOF-MS (E) identification of urinary metabolites of the emerging sport nutrition supplement methoxyisoflavone in human subjects. J Pharm Biomed Anal. 2014 Aug 5;96:127-34. |[5]Lee S, et al., Isoflavone derivatives inhibit NF-κB-dependent transcriptional activity. Bioorg Med Chem Lett. 2010 Nov 1;20 (21) :6277-81.|[6]Hyun J, et al., Isoflavones inhibit the clonogenicity of human colon cancer cells. Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2664-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

5-Methyl-7-methoxyisoflavone

a performance-enhancing drug; structure in first source

CAS Number82517-12-2
PubChem CID2734290
IUPAC Name7-methoxy-5-methyl-3-phenylchromen-4-one
Molecular FormulaC17H14O3
Molecular Weight266.29
XLogP3.5
Topological Polar Surface Area35.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity395
SMILES
CC1=CC(=CC2=C1C(=O)C(=CO2)C3=CC=CC=C3)OC
InChI
InChI=1S/C17H14O3/c1-11-8-13(19-2)9-15-16(11)17(18)14(10-20-15)12-6-4-3-5-7-12/h3-10H,1-2H3
InChIKey
WGOUYULOZZRTFS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-Methyl-7-methoxyisoflavone
CAS: 82517-12-2
CID: 2734290
Formula: C17H14O3
MW: 266.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight266.29
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass266.094294304
Monoisotopic Mass266.094294304
Topological Polar Surface Area35.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity395
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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