(S) -Tersolisib

• Description:

  (S) -STX-478 is the S-enantiomer of STX-478. STX-478 is a selective inhibitor of PI3Kα mutants, preventing metabolic dysfunction and demonstrating antitumor activity in xenograft mouse models with PI3Kα mutant tumors[1].

• Product Name Alternative:

  (S) -STX-478

• UNSPSC:

  12352005

• Target:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-stx-478.html

• Purity:

  99.18

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=NC=C(C=N1)NC(N[C@@H](C2=C(C3=CC(F)=CC(F)=C3O2)C)C(F)(F)F)=O

• Molecular Formula:

  C16H12F5N5O2

• Molecular Weight:

  401.29

• References & Citations:

  [1]Buckbinder L, et al. STX-478, a mutant-selective, allosteric PI3Kα inhibitor spares metabolic dysfunction and improves therapeutic response in PI3Kα-mutant xenografts[J]. Cancer Discovery, 2023, 13 (11) : 2432-2447.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2883540-91-6]