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Oct4 Antibody / POU5F1

CAT: 0013-GTR18571564Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571564Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oct4 Transcription factor that binds to the octamer motif (5) . Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2. Transcriptional activity is positively regulated by PKM2. Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. Belongs to the POU transcription factor family. Class- 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt
Q01860
Reactivity
Human
Immunogen
A portion of amino acids 1-134 was used as the immunogen for the Oct4. antibody.
Clonality
Monoclonal
Clone
Oct4/3508
Conjugation
Unconjugated
Field of Research
Stem Cell & Developmental Biology
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Oct4 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · Q01860

POU domain, class 5, transcription factor 1

PO5F1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q01860
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POU5F1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NCS1, A6NLL8, D2IYK4, P31359, Q15167, Q15168, Q16422, Q5STF3, Q5STF4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Molecular function

Developmental proteinDNA-binding

Domain

Homeobox

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

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