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POU5F1 Antibody / Oct4

CAT: 0800-RQ6789Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6789Size:100 µg
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Description
Oct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded by the POU5F1 gene. It is mapped to 6p21.33. This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
Q01860
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids ENLQEICKAETLVQARK from the human protein were used as the immunogen for the POU5F1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the POU5F1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This POU5F1 antibody is available for research use only.
Storage Conditions
After reconstitution, the POU5F1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the POU5F1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human HeLa, 2) human placenta, 3) rat heart, 4) rat brain, 5) mouse heart, 6) mouse brain and 7) mouse NIH 3T3 cell lysate with POU5F1 antibody. Predicted molecular weight ~38/30 kDa (isoform A/B), commonly observed at 38-45 kDa.

UniProtKB · Q01860

POU domain, class 5, transcription factor 1

PO5F1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q01860
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POU5F1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NCS1, A6NLL8, D2IYK4, P31359, Q15167, Q15168, Q16422, Q5STF3, Q5STF4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Molecular function

Developmental proteinDNA-binding

Domain

Homeobox

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

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