Amikacin (disulfate)

Amikacin (disulfate)

• CAS Number: 39831-55-5
• UNSPSC Description: Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Cancer
• Assay Protocol: https://www.medchemexpress.com/Amikacin-sulfate.html
• Purity: 98.0
• Solubility: DMSO : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic)
• Smiles: OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO
• Molecular Weight: 781.76
• References & Citations: [1]Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28.|[2]Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25.|[3]Siân R Kitcher, et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764.ACS Chem Biol. 2021 Dec 15.|bioRxiv. 2024 May 10.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Nat Commun. 2022 Mar 2;13(1):1116.|ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.|Int J Med Microbiol. 2023 Mar 28;313(2):151578.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702.|Curr Microbiol. 2021 Dec 14;79(1):12.|J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched