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Amikacin

CAT: 0804-HY-B0509A-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0509A-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amikacin (BAY 41-6551) is a semisynthetic kanamycin analog that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains. Significant inhibitory effect. Amikacin is ototoxic and nephrotoxic. Amikacin can be used in bacteriostatic, anti-cancer and analgesic studies[1][2][3][4][5].
CAS Number
37517-28-5
Product Name Alternative
BAY 41-6551
UNSPSC
12352005
Hazard Statement
H317
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/amikacin.html
Purity
99.93
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO
Molecular Formula
C22H43N5O13
Molecular Weight
585.60
Precautions
H317
References & Citations
[1]Farhan SM, et al. In Vitro and In Vivo Effect of Amikacin and Imipenem Combinations against Multidrug-Resistant E. coli. Trop Med Infect Dis. 2022 Oct 2;7 (10) :281. |[2]Wang YH, et al. Amikacin Suppresses Human Breast Cancer Cell MDA-MB-231 Migration and Invasion. Toxics. 2020 Nov 20;8 (4) :108. |[3]Atamer-Simsek S, et al. Antinociceptive effect of amikacin and its interaction with morphine and naloxone. Pharmacol Res. 2000 Mar;41 (3) :355-60. |[4]Ladrech S, et al. Calpain activity in the amikacin-damaged rat cochlea. J Comp Neurol. 2004 Sep 13;477 (2) :149-60. |[5]Chan K, et al. Characterization of Amikacin Drug Exposure and Nephrotoxicity in an Animal Model. Antimicrob Agents Chemother. 2020 Aug 20;64 (9) :e00859-20.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Aminoglycoside
Citation 01
ACS Infect Dis. 2024 Apr 12;10 (4) :1327-1338.|AMB Express. 2024 Dec 24;14 (1) :141.|Antimicrob Agents Chemother. 2024 Oct 29:e0094524.|Antimicrob Agents Chemother. 2025 May 23:e0024925.|Authorea. 2025 Sep 17.|bioRxiv. 2025 May 30.|Commun Biol. 2025 Oct 6;8 (1) :1425.|EBioMedicine. 2025 May 30:117:105776.|Eur J Clin Microbiol Infect Dis. 2025 Jun;44 (6) :1493-1500.|Eur J Clin Microbiol Infect Dis. 2025 Sep 29.|Int J Antimicrob Agents. 2025 Jun 9:107551.|Int J Med Microbiol. 2023 Mar 28;313 (2) :151578.|J Antimicrob Chemother. 2020 Sep 1;75 (9) :2609-2615.|J Clin Microbiol. 2025 Aug 20:e0084125.|Microbiol Spectr. 2025 May 19:e0307424.|Pathogens. 2025 Mar 21;14 (4) :302.|ACS Chem Biol. 2022 Jan 21;17 (1) :39-53.|bioRxiv. 2024 May 10.|Int J Antimicrob Agents. 2018 Aug;52 (2) :269-271.|Nat Commun. 2022 Mar 2;13 (1) :1116.|Antibiotics (Basel) . 2021 Sep 14;10 (9) :1110.|Appl Microbiol Biotechnol. 2022 Apr;106 (7) :2689-2702.|Curr Microbiol. 2021 Dec 14;79 (1) :12.|J Antimicrob Chemother. 2020 Jul 1;75 (7) :1850-1858.

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