Amikacin

• UNSPSC Description:

  Amikacin (BAY 41-6551) is a semisynthetic kanamycin analog that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains. Significant inhibitory effect. Amikacin is ototoxic and nephrotoxic. Amikacin can be used in bacteriostatic, anti-cancer and analgesic studies[1][2][3][4][5].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/amikacin.html

• Purity:

  99.93

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO

• Molecular Weight:

  585.60

• References & Citations:

  [1]Farhan SM, et al. In Vitro and In Vivo Effect of Amikacin and Imipenem Combinations against Multidrug-Resistant E. coli. Trop Med Infect Dis. 2022 Oct 2;7(10):281. |[2]Wang YH, et al. Amikacin Suppresses Human Breast Cancer Cell MDA-MB-231 Migration and Invasion. Toxics. 2020 Nov 20;8(4):108. |[3]Atamer-Simsek S, et al. Antinociceptive effect of amikacin and its interaction with morphine and naloxone. Pharmacol Res. 2000 Mar;41(3):355-60. |[4]Ladrech S, et al. Calpain activity in the amikacin-damaged rat cochlea. J Comp Neurol. 2004 Sep 13;477(2):149-60. |[5]Chan K, et al. Characterization of Amikacin Drug Exposure and Nephrotoxicity in an Animal Model. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00859-20. ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.|Int J Med Microbiol. 2023 Mar 28;313(2):151578.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.|ACS Chem Biol. 2021 Dec 15.|bioRxiv. 2024 May 10.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Nat Commun. 2022 Mar 2;13(1):1116.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702.|Curr Microbiol. 2021 Dec 14;79(1):12.|J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  37517-28-5