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E3 ligase Ligand 45

CAT: 0804-HY-168699Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168699Size:1 Each
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Description
E3 ligase Ligand 45 is an E3 ligase ligand that can be used to synthesize the PROTAC degrader Setidegrasib for Ras[1].
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-45.html
Smiles
O=C(N(C[C@@H]1O)[C@@H](C1)C(N[C@H](C2=CC=C(C(SC=N3)=C3C)C=C2)CO)=O)[C@@H](O)C(C)C
Molecular Formula
C22H29N3O5S
Molecular Weight
447.55
References & Citations
[1]Yoshinari, et al. Preparation of quinazoline-linked (4R) -4-hydroxy-L-prolinamide compounds for inducing degradation of G12D-mutation KRAS protein: World Intellectual Property Organization, WO2022173032[P]. 2022-08-18.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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