L-674573

CAT: 0804-HY-120571-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-120571-02Size:10 mg

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Description

L-674573 is a quinoline leukotriene synthesis inhibitor, inhibiting Calcimycin - and N-Formyl-Met-Leu-Phe (HY-P0224) -induced leukotriene production with IC50s of 100 nM and 50 nM, respectively. L-674573 selectively inhibits Calcimycin- and N-Formyl-Met-Leu-Phe-induced 5-lipoxygenase translocation[1].

CAS Number

127481-29-2

UNSPSC

12352005

Target

Leukotriene Receptor; Lipoxygenase

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-674573.html

Purity

99.54

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(CSC(CCCC1=CC=CC=C1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)O

Molecular Formula

C28H27NO3S

Molecular Weight

457.58

References & Citations

[1]S Kargman, et al. Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. J Biol Chem. 1991 Dec 15;266 (35) :23745-52.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

L 674573

structure given in first source

CAS Number	127481-29-2
PubChem CID	124437
IUPAC Name	2-[4-phenyl-1-[4-(quinolin-2-ylmethoxy)phenyl]butyl]sulfanylacetic acid
Molecular Formula	C28H27NO3S
Molecular Weight	457.6
XLogP	6.4
Topological Polar Surface Area	84.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Heavy Atom Count	33
Formal Charge	0
Complexity	573

SMILES

C1=CC=C(C=C1)CCCC(C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)SCC(=O)O

InChI

InChI=1S/C28H27NO3S/c30-28(31)20-33-27(12-6-9-21-7-2-1-3-8-21)23-14-17-25(18-15-23)32-19-24-16-13-22-10-4-5-11-26(22)29-24/h1-5,7-8,10-11,13-18,27H,6,9,12,19-20H2,(H,30,31)

InChIKey

JOIXGLLMSDPZDN-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 127481-29-2

CID: 124437

Formula: C28H27NO3S

MW: 457.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	457.6
XLogP3	6.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Exact Mass	457.17116490
Monoisotopic Mass	457.17116490
Topological Polar Surface Area	84.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	573
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
T24327-01	L 674573
BA5451-10	L-674573
CCP1053-01	A-L-A-L
453309-01	L-Glycyl-L-lysyl-L-leucyl-L-isoleucyl-L-tyrosyl-L-seryl-L-alanyl-L-seryl-L-phenylalanyl-L-leucyl-L-tyrosyl-L-seryl-L-glycyl-L-valyl-L-prolyl-L-seryl-L-arganine
453434-01	L-Seryl-L-threonyl-L-glycyl-L-isoleucyl-L-seryl-L-valyl-L-prolyl-L-glycyl-L-prolyl-L-methionyl-L-glycyl-L-prolyl-L-seryl-L-glycyl-L-prolyl-L-Arginine
JH918176	L-Arginine, L-valyl-L-seryl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginylglycylglycyl-L-arginyl-L-arginyl-L-arginyl-
453216-01	L-Arginyl-L-valyl-L-α-aspartyl-L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine
453308-01	L-Glycyl-L-arginyl-L-phenylalanyl-L-isoleucyl-L-threonyl-L-seryl-L-alanyl-L-aspartyl-L-threonyl-L-lysine
918629-48-8	L-Alanyl-L-Cysteinyl-L-Seryl-L-Seryl-L-Seryl-L-Prolyl-L-Seryl-L-Lysyl-L-Histidyl-L-Cysteinylglycine
453464-01	L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine

L-674573

Chemical Information

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