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L-674573

CAT: 0804-HY-120571-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120571-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-674573 is a quinoline leukotriene synthesis inhibitor, inhibiting Calcimycin - and N-Formyl-Met-Leu-Phe (HY-P0224) -induced leukotriene production with IC50s of 100 nM and 50 nM, respectively. L-674573 selectively inhibits Calcimycin- and N-Formyl-Met-Leu-Phe-induced 5-lipoxygenase translocation[1].
CAS Number
127481-29-2
UNSPSC
12352005
Target
Leukotriene Receptor; Lipoxygenase
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-674573.html
Purity
99.54
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(CSC(CCCC1=CC=CC=C1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)O
Molecular Formula
C28H27NO3S
Molecular Weight
457.58
References & Citations
[1]S Kargman, et al. Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. J Biol Chem. 1991 Dec 15;266 (35) :23745-52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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