Triacetin

CAT: 0804-HY-B0896-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-B0896-01Size:1 g
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Description
Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid, orally active. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1][2].
CAS Number
[102-76-1]
Product Name Alternative
Glyceryl triacetate; 1,2,3-Triacetoxypropane
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Triacetin.html
Purity
99.87
Solubility
DMSO : 300 mg/mL (ultrasonic)
Smiles
CC(OCC(OC(C)=O)COC(C)=O)=O
Molecular Formula
C9H14O6
Molecular Weight
218.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Tsen AR, et al. Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. Int J Cancer. 2014 Mar 15;134 (6) :1300-10.|[2]Mekala JR, et al. N-acetyl l-aspartate and Triacetin modulate tumor suppressor MicroRNA and class I and II HDAC gene expression induce apoptosis in Glioblastoma cancer cells in vitro. Life Sci. 2021 Dec 1;286:120024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

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