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H2-Gamendazole

CAT: 0804-HY-153911-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153911-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research[1].
CAS Number
877768-84-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
CFTR; HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/h2-gamendazole.html
Purity
98.20
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CCC1=NN(CC2=CC=C(C=C2Cl)Cl)C3=C1C=CC(C(F)(F)F)=C3)O
Molecular Formula
C18H13Cl2F3N2O2
Molecular Weight
417.21
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Shirin V Sundar, et al. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1;323 (4) :F492-F506.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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