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Prostaglandin H2

CAT: 0804-HY-136500-01Size: 10 μg (283.71 μM x 100 μL in Acetone)Dry Ice: NoHazardous: No
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CAT#:0804-HY-136500-01Size:10 μg (283.71 μM x 100 μL in Acetone)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor. Prostaglandin H2 can cause vasoconstriction. Prostaglandin H2 is the common precursor of all PGs and is produced by several cells that express cyclooxygen-ases. Prostaglandin H2 can activate PGD2 receptors CRTH2 and DP via interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. Prostaglandin H2 can induce eosinophils migration and inhibit platelet aggregation. Prostaglandin H2 can accelerate the formation of dimers and higher oligomers of amyloid β1-42. Prostaglandin H2 can be used for the researches of inflammation and neurological disease, such as Alzheimer disease[1][2][3].
CAS Number
42935-17-1
Product Name Alternative
PGH2
UNSPSC
12352005
Hazard Statement
H225, H302+H312+H332, H319
Target
Amyloid-β; Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/prostaglandin-h2.html
Concentration
283.71 μM * 100 μL in Acetone
Purity
95.0
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@]2([H])C[C@@]1([H])OO2)C/C=C\CCCC(O)=O
Molecular Formula
C20H32O5
Molecular Weight
352.47
Precautions
H225, H302+H312+H332, H319
References & Citations
[1]Schuligoi R, et al. Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2. J Leukoc Biol. 2009 Jan;85 (1) :136-45.|[2]Boutaud O, et al. Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J Neurochem. 2002 Aug;82 (4) :1003-6.|[3]Saito M, et al. Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery. Eur J Pharmacol. 2003 Apr 25;467 (1-3) :151-61.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Prostaglandin H2

Prostaglandin H2 is a prostaglandins H, a secondary alcohol, an oxylipin and an olefinic compound. It has a role as a mouse metabolite. It is a conjugate acid of a prostaglandin H2(1-).

CAS Number42935-17-1
PubChem CID445049
IUPAC Name(Z)-7-[(1R,4S,5R,6R)-6-[(E,3S)-3-hydroxyoct-1-enyl]-2,3-dioxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid
Molecular FormulaC20H32O5
Molecular Weight352.5
XLogP3.8
Topological Polar Surface Area76
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Heavy Atom Count25
Formal Charge0
Complexity459
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)OO2)O
InChI
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
InChIKey
YIBNHAJFJUQSRA-YNNPMVKQSA-N
Chemical Structure
2D Structure
2D structure of Prostaglandin H2
CAS: 42935-17-1
CID: 445049
Formula: C20H32O5
MW: 352.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.5
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass352.22497412
Monoisotopic Mass352.22497412
Topological Polar Surface Area76 Ų
Heavy Atom Count25
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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