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Recombinant Human Coagulation factor VII (F7), partial

CAT: 0399-CSB-EP007930HU-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP007930HU-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
Proconvertin Serum prothrombin conversion accelerator Short name: SPCA INN: Eptacog alfa Cleaved into the following 2 chains: Factor VII light chain Factor VII heavy chain
Abbreviation
Recombinant Human F7 protein, partial
Gene Name
F7
UniProt
P08709
Expression Region
61-212aa
Organism
Homo sapiens (Human)
Target Sequence
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGR
Tag
N-terminal 6xHis-SUMO-tagged
Type
In Stock Protein
Source
E.coli
Field of Research
Cardiovascular
Relevance
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Endotoxin
Not test
Purity
Greater than 90% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Function
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Molecular Weight
33 kDa
References & Citations
"Characterization of a cDNA coding for human factor VII."Hagen F.S., Gray C.L., O'Hara P.J., Grant F.J., Saari G.C., Woodbury R.G., Hart C.E., Insley M.Y., Kisiel W., Kurachi K., Davie E.W.Proc. Natl. Acad. Sci. U.S.A. 83:2412-2416 (1986)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Partial

UniProtKB · P08709

Coagulation factor VII

FA7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08709
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
F7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.21
Processing
Precursor
Secondary accessions
B0YJC8, Q14339, Q5JVF1, Q5JVF2, Q9UD52, Q9UD53, Q9UD54
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

Ligand

Calcium

PTM

Cleavage on pair of basic residuesDisulfide bondGamma-carboxyglutamic acidGlycoproteinHydroxylationZymogen

Disease

Disease variant

Domain

EGF-like domainRepeatSignal

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

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