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Recombinant Human Bone morphogenetic protein 7 (BMP7)

CAT: 0399-CSB-EP002744HUe0-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP002744HUe0-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
Osteogenic protein 1 ; OP-1INN: Eptotermin alfa
Abbreviation
Recombinant Human BMP7 protein
Gene Name
BMP7
UniProt
P18075
Expression Region
293-431aa
Organism
Homo sapiens (Human)
Target Sequence
STGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
Tag
N-terminal GST-tagged
Type
In Stock Protein
Source
E.coli
Field of Research
Developmental Biology
Relevance
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Endotoxin
Not test
Purity
Greater than 90% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Function
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Molecular Weight
42.7 kDa
References & Citations
Expression and characterization of a human BMP-7 variant with improved biochemical properties.Swencki-Underwood B., Mills J.K., Vennarini J., Boakye K., Luo J., Pomerantz S., Cunningham M.R., Farrell F.X., Naso M.F., Amegadzie B.Protein Expr. Purif. 57:312-319 (2008)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Full Length of Mature Protein

UniProtKB · P18075

Bone morphogenetic protein 7

BMP7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18075
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BMP7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BMP-7
EC number
—
Processing
Precursor
Secondary accessions
Q9H512, Q9NTQ7
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Biological process

ChondrogenesisDifferentiationOsteogenesis

Molecular function

CytokineDevelopmental proteinGrowth factor

PTM

Disulfide bondGlycoprotein

Cellular component

Secreted

Domain

Signal