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Recombinant Human Bone morphogenetic protein 4 (BMP4)

CAT: 0399-CSB-EP002740HU-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP002740HU-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
Bone morphogenetic protein 2B ; BMP-2B
Abbreviation
Recombinant Human BMP4 protein
Gene Name
BMP4
UniProt
P12644
Expression Region
293-408aa
Organism
Homo sapiens (Human)
Target Sequence
SPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Tag
N-terminal 6xHis-SUMO-tagged
Type
In Stock Protein
Source
E.coli
Field of Research
Developmental Biology
Relevance
Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during bryonic mammary development and to inhibit hair follicle induction .
Endotoxin
Not test
Purity
Greater than 90% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Function
Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) .
Molecular Weight
29.1 kDa
References & Citations
Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip.Suzuki S., Marazita M.L., Cooper M.E., Miwa N., Hing A., Jugessur A., Natsume N., Shimozato K., Ohbayashi N., Suzuki Y., Niimi T., Minami K., Yamamoto M., Altannamar T.J., Erkhembaatar T., Furukawa H., Daack-Hirsch S., L'heureux J. , Brandon C.A., Weinberg S.M., Neiswanger K., Deleyiannis F.W., de Salamanca J.E., Vieira A.R., Lidral A.C., Martin J.F., Murray J.C.Am. J. Hum. Genet. 84:406-411 (2009)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Full Length of Mature Protein

UniProtKB · P12644

Bone morphogenetic protein 4

BMP4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12644
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BMP4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BMP-4
EC number
—
Processing
Precursor
Secondary accessions
Q9UM80
Protein keywords

Biological process

ChondrogenesisDifferentiationOsteogenesis

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoprotein

Molecular function

CytokineDevelopmental proteinGrowth factor

Disease

Disease variantMicrophthalmia

Cellular component

Extracellular matrixSecreted

Technical term

Proteomics identificationReference proteome

Domain

Signal

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Alternative Products

CatalogName
030812BMP4 (BMP4, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B)
308097-01Bone Morphogenetic Protein 4 (BMP4)
029996BMP4 (Bone morphogenetic protein 4)
GTR19145288-01Bone Morphogenetic Protein 4, BMP4
030812-PEBMP4 (BMP4, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B) (PE) discontinued
030812-HRPBMP4 (BMP4, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B) (HRP) discontinued
030812-FITCBMP4 (BMP4, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B) (FITC) discontinued
030812-APCBMP4 (BMP4, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B) (APC) discontinued
030812-APBMP4 (BMP4, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B) (AP) discontinued
030812-BiotinBMP4 (BMP4, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B) (Biotin) discontinued

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