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LGD-2226

CAT: 0804-HY-105318-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105318-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LGD-2226 is a selective and orally active androgen receptor modulator with an EC50 of 0.2 nM and a Ki of 1.5 nM for human androgen receptor. LGD-2226 shows tissue selectivity in animal models, with reduced effects on prostate compared to muscle. LGD-2226 can be used for muscle wasting, osteoporosis and sexual dysfunction[1][2].
CAS Number
328947-93-9
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor
Type
Biochemical Assay Reagents
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lgd-2226.html
Purity
98.58
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=C(N(CC(F)(F)F)CC(F)(F)F)C=C2)C(C(F)(F)F)=C1
Molecular Formula
C14H9F9N2O
Molecular Weight
392.22
Precautions
H302, H315, H319, H335
References & Citations
[1]van Oeveren A, et al. Discovery of 6-N, N-bis (2,2,2-trifluoroethyl) amino- 4-trifluoromethylquinolin-2 (1H) -one as a novel selective androgen receptor modulator. J Med Chem. 2006 Oct 19;49 (21) :6143-6.|[2]Miner JN, et al. An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate. Endocrinology. 2007 Jan;148 (1) :363-73.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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