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Thalidomide-NH-PEG3-propionic acid

CAT: 0804-HY-136166-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136166-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
CAS Number
2138440-82-9
UNSPSC
12352005
Hazard Statement
H361
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-nh-peg3-propionic-acid.html
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Molecular Formula
C22H27N3O9
Molecular Weight
477.46
Precautions
H361
References & Citations
[1]David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56 (21) :5738-5743.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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