Prion protein Antibody (PrP)

• Catalog number
  R30893
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Prion protein (PrP)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Prion protein antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Prion protein antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P04925
• Purity
  Antigen affinity
• Description
  Prion protein, also known as CD230 and PRP, is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al.(1991) identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru.
• Immunogen
  An amino acid sequence from the middle region of mouse Prion protein (DWEDRYYRENMYRYPNQ) was used as the immunogen for this Prion protein antibody (100% rat homology).
• Storage
  After reconstitution, the Prion protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Prion   protein   PrP  
• Gene symbol
  PRNP
• Short name
  Anti-Prion protein (PrP)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Prion protein (PrP)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9449
• Gene
  PRNP
• Long gene name
  prion protein
• Synonyms gene
  • PRIP
  • GSS
  • CJD
• Synonyms gene name
  • prion protein (p27-30)
• Synonyms
  • CD230
  • PRP
  • AltPrP
• Synonyms name
  • Creutzfeldt-Jakob disease
  • Gerstmann-Strausler-Scheinker syndrome
  • fatal familial insomnia
  • p27-30
• GenBank acession
  • M13899
• Locus
  20p13
• Discovery year
  1986-01-01
• Entrez gene record
  5621
• RefSeq identity
  • NM_000311
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000031786
• Locus Specific Databases
  • Prion Protein/CJD database

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products