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Stock availabilitIn Stock
In Stock
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CAS number
No Available. See included datasheet
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Description
Hsp25 Kinase Inhibitor
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Molecular weight
1396,7 g/mol
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Primary research fields
Cancer, Heat Shock
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Other name
none
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C61H113N21O6
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Origin
Synthetic
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Purity pourcentage
>95%
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Soluble in
Soluble in DMSO or H20
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
Refer to PubChem
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Scientific context
The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). In particular, MAPKAP-kinase II (or otherwise known as MK2) is involved in inflammation, and is considered a target for therapeutic intervention for inflammation and cancer (3). MK2 is a member of the p38 MAPKinase pathway, and is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (3).
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Bibliography
1. Pearson G. et al. (2001). Endocrine Reviews 22 (2): 153-183. 2. Fan Y., et al. (2007) Mol. Cells 23 (1): 30-38. 3. Deng et al. (2003) Cell 115: 61-70.
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure link
No representative figure available at this time.
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Representative figure legend
No representative figure available at this time.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
