-
Stock availabilitIn Stock
In Stock
-
CAS number
No Available. See included datasheet
-
Description
S6 kinase inhibitor
-
Molecular weight
445,4 g/mol
-
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
-
Other name
4-(4-(4-(4-fluoro-3-(trifluoromethyl) phenyl)-1-methyl-1H-imidazol-2-yl) piperidin-1-yl)-1H-pyrazolo [3,4-d] pyrimidine
-
Product category
Small Molecules
-
Product type
Inhibitor
-
Chemical formula
C21H19F4N7
-
Origin
Synthetic
-
Purity pourcentage
97% (HPLC)
-
Soluble in
Soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming)
-
Physical appearance
Yellow solid
-
Storage recommendations
-20ºC
-
Shipping recommendations
Shipped Ambient
-
Safety information
Classification: Skin Category 2 Eye Category 2A Specific target organ toxicity - single exposure (Category 3 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
-
PubChem number
25118925
-
Scientific context
LYS6K2 is a selective inhibitor of the p70 ribosomal S6 kinase. Specifically, it blocks the phosphorylation of S6. LYS6K2 is cell permeable.
-
Bibliography
1. Fenton T.R., & Gout I.T. (2011) Int. J. Biochem. Cell Biol. 43(1): 47–59.
-
Release date
1-Oct-2014
-
PubMed number
Refer to PubMed
-
Tested applications
To be tested
-
Tested reactivity
To be tested
-
-
Representative figure legend
Chemical structure of LYS6K2 (SIH-462), a S6 kinase inhibitor. CAS #: N/A. Molecular Formula: C21H19F4N7. Molecular Weight: 445.4 g/mol. Chemical structure of LYS6K2, a S6 kinase inhibitor (SIH-462). CAS # N/A. Molecular Formula: C21H19F4N7.
-
Warning information
Non-hazardous
-
Country of production
Canada
-
Total weight kg
0.25
-
Net weight g
0.005
-
-
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
