LSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-containing Amine Oxidase Domain-containing Protein 2, KDM1A, AOF2, KDM1, KIAA0601)
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Catalog numberMBS644623
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PricePlease ask
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Size0.05 mg
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Products_typeAntibody
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Products_short_name[LSD1]
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Products_name_syn[Anti -LSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-containing Amine Oxidase Domain-containing Protein 2, KDM1A, AOF2, KDM1, KIAA0601)]
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Other_names[lysine-specific histone demethylase 1A; lysine-specific histone demethylase 1A; lsd1; lysine (K)-specific demethylase 1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethylase 1a]
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Other_gene_names[kdm1a; aof2; kdm1; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06]
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ClonalityPolyclonal
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ReactivityHuman
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SpecificityRecognizes human KDM1A. Species sequence homology: Mouse, rat.
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PurityAffinity Purified Purified by immunoaffinity chromatography.
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FormSupplied as a liquid in PBS, 0.02% sodium azide.
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Storage_stabilityMay be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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Tested_applicationWestern Blot (WB), Immunohistochemistry (IHC)
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GeneLysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.
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Gene target
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Gene symbolKDM1A, HDAC4, HDAC9, HMG20B
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Short nameLSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin- Amine Oxidase Domain- Protein 2, KDM1A, AOF2, KDM1, KIAA0601)
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HostRabbit
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Alternative nameLSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC aggregate Protein BHC110, Flavin-containing Amine Oxidase Domain-containing Protein 2, KDM1A, AOF2, KDM1, KIAA0601)
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Gene info
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Identity
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Gene
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Long gene namelysine demethylase 1A
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Synonyms gene
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Synonyms gene name
- amine oxidase (flavin containing) domain 2
- lysine (K)-specific demethylase 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-02-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
- Lysine demethylases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namehigh mobility group 20B
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Synonyms gene name
- high-mobility group 20B
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-06-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Non-canonical high mobility group
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VEGA ID