LSD1 (Lysine-Specific Histone Demethylase, Amine Oxidase Flavin-containing Domain Protein 2, AOF2)

• Catalog number
  MBS613560
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [LSD1]
• Products_name_syn
  [Anti -LSD1 (Lysine-Specific Histone Demethylase, Amine Oxidase Flavin-containing Domain Protein 2, AOF2)]
• Other_names
  [LSD1]
• Clonality
  Polyclonal
• Reactivity
  Human, Mouse, Rat
• Specificity
  Recognizes human. Species Crossreactivity: mouse and rat
• Purity
  Affinity Purified Purified by immunoaffinity chromatography.
• Form
  Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
• Storage_stability
  May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  Western Blot (WB)
• Gene
  Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.

• Gene target
  LSD1   Lysine-Specific   Histone   Demethylase   Amine   Oxidase   Flavin   Domain   Protein   AOF2  
• Gene symbol
  KDM1A
• Short name
  LSD1 (Lysine-Specific Histone Demethylase, Amine Oxidase Flavin- Domain Protein 2, AOF2)
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  LSD1 (Lysine-Specific Histone Demethylase, Amine Oxidase Flavin-containing Domain Protein 2, AOF2)

Gene info

• Identity
  HGNC:29079
• Gene
  KDM1A
• Long gene name
  lysine demethylase 1A
• Synonyms gene
  • AOF2
  • KDM1
• Synonyms gene name
  • amine oxidase (flavin containing) domain 2
  • lysine (K)-specific demethylase 1
• Synonyms
  • KIAA0601
  • BHC110
  • LSD1
• Synonyms name
  • Lysine-specific histone demethylase 1A
• GenBank acession
  • AL031428
• Locus
  1p36.12
• Discovery year
  2004-02-26
• Entrez gene record
  23028
• Pubmed identfication
  • 9628581
  • 12493763
• RefSeq identity
  • NM_015013
• Classification
  • MicroRNA protein coding host genes
  • Lysine demethylases
• VEGA ID
  OTTHUMG00000003220

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