LSD1, NT (Lysine-specific Histone Demethylase 1A, Amine Oxidase Flavin Containing Domain Protein 2, BRAF35-HDAC Complex Protein BHC110, AOF2, KIAA0601, KDM1)
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Catalog number
MBS627873
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Price
Please ask
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Size
0,2 mL
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Other size
please contact us to order other different size
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Gene
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.
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Gene target
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Gene symbol
KDM1A, HDAC4, HDAC9, HMG20B
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Short name
LSD1, NT (Lysine-specific Histone Demethylase 1A, Amine Oxidase Flavin Domain Protein 2, BRAF35-HDAC Complex Protein BHC110, AOF2, KIAA0601, KDM1)
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Alternative name
LSD1, NT (Lysine-specific Histone Demethylase 1A, Amine Oxidase Flavin Containing Domain Protein 2, BRAF35-HDAC aggregate Protein BHC110, AOF2, KIAA0601, KDM1)
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Gene info
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Identity
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Gene
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Long gene name
lysine demethylase 1A
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Synonyms gene
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Synonyms gene name
- amine oxidase (flavin containing) domain 2
- lysine (K)-specific demethylase 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2004-02-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
- Lysine demethylases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
histone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year
2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
histone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year
2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
high mobility group 20B
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Synonyms gene name
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1999-06-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Non-canonical high mobility group
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VEGA ID
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