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Target antigen
XIAP
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
mouse, rat
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human XIAP(14-34aa ADINKEEEFVEEFNRLKTFAN), different from the related mouse sequence by two amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the XIAP Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The XIAP Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
BIRC4, baculoviral IAP repeat-containing protein 4 is also known as XIAP(X-linked inhibitor of apoptosis protein). The BIRC4 gene comprises 6 exons. This gene is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
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Related articles
1. Cummins, J. M., Kohli, M., Rago, C., Kinzler, K. W., Vogelstein, B., Bunz, F.X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.Cancer Res. 64: 3006-3008, 2004. 2. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., Reed, J. C.X-linked IAP is a direct inhibitor of cell-death proteases.Nature 388: 300-304, 1997. 3. Kim, J., Park, J., Choi, S., Chi, S.-G., Mowbray, A. L., Jo, H., Park, H.X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival.Circ. Res. 102: 896-904, 2008.
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Gene Name
XIAP
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Protein Name
E3 ubiquitin-protein ligase XIAP
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Gene Full Name
X-linked inhibitor of apoptosis
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Synonyms
AP 13 antibody|API3 antibody|Apoptosis Inhibitor 3 antibody|Baculoviral IAP repeat containing 4 antibody|Baculoviral IAP Repeat Containing Protein 4 antibody|Baculoviral IAP repeat-containing protein 4 antibody|BIRC 4 antibody|BIRC4 antibody|E3 ubiquitin-protein ligase XIAP antibody|hIAP-3 antibody|hIAP3 antibody|HILP antibody|IAP 3 antibody|IAP like protein antibody|IAP-3 antibody|IAP-like protein antibody|IAP3 antibody|ILP 1 antibody|ILP antibody|ILP1 antibody|Inhibitor of apoptosis protein 3 antibody|Inhibitor of Apoptosis X Linked antibody|Mammalian IAP Homologue A antibody|MIHA antibody|X linked IAP antibody|X linked inhibitor of apoptosis antibody|X linked inhibitor of apoptosis protein antibody|X-linked IAP antibody|X-linked inhibitor of apoptosis protein antibody|Xiap antibody|XIAP_HUMAN antibody|XLP2 antibody
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Uniprot ID
P98170
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
