XIAP Antibody

• Catalog number
  R30585
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  XIAP
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the XIAP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This XIAP antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P98170
• Purity
  Antigen affinity
• Description
  BIRC4, baculoviral IAP repeat-containing protein 4 is also known as X-linked inhibitor of apoptosis protein, or XIAP. The BIRC4 gene comprises 6 exons. This gene is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
• Immunogen
  An amino acid sequence from the N-terminus of human XIAP (ADINKEEEFVEEFNRLKTFAN) was used as the immunogen for this XIAP antibody.
• Storage
  After reconstitution, the XIAP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  XIAP  
• Gene symbol
  XIAP-AS1, XIAP
• Short name
  Anti-XIAP
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to XIAP
• Alternative technique
  antibodies
• Alternative to gene target
  X-linked inhibitor of apoptosis, XIAP and IDBG-85142 and ENSG00000101966 and 331, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, nuclei

Gene info

• Identity
  HGNC:40078
• Gene
  XIAP-AS1
• Long gene name
  XIAP antisense RNA 1
• Synonyms gene name
  • XIAP antisense RNA 1 (non-protein coding)
• Locus
  Xq25
• Discovery year
  2011-07-28
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000022339

Gene info

• Identity
  HGNC:592
• Gene
  XIAP
• Long gene name
  X-linked inhibitor of apoptosis
• Synonyms gene
  • API3
  • BIRC4
• Synonyms gene name
  • baculoviral IAP repeat-containing 4
  • X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
• Synonyms
  • hILP
  • ILP-1
• Synonyms name
  • IAP-like protein 1
• GenBank acession
  • U45880
• Locus
  Xq25
• Discovery year
  1998-06-10
• Entrez gene record
  331
• Pubmed identfication
  • 8552191
  • 8654366
  • 15749826
• RefSeq identity
  • NM_001167
• Classification
  • Ring finger proteins
  • Baculoviral IAP repeat containing
• VEGA ID
  OTTHUMG00000022336
• Locus Specific Databases
  • BIRC4base: Mutation registry for X-linked lymphoproliferative syndrome
  • Global Variome shared LOVD
  • LRG_19

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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